REPUBLIC OF GHANA
MINISTRY OF HEALTH
SCIENTIFIC RESEARCH INTO PLANT MEDICINE
FOR RESEARCH & DEVELOPMENT OF TRADITIONAL MEDICINE
REPORT ON PHYTOCHEMICAL
ANALYSIS AND SAFETYASSESSMENT OF "ASTHFIN Al"
Ref. No. CPM/A34/SFI/393: 27
- 01 2004
"Asthfin A1" is a herbal
preparation submitted to the Centre for Scientific Rescarch into
Plant Medicine for phytochemical analysis and safety assessment.
According to the manufacturer, the Medicine, mixed wíth
honey is recommended for the treatment of "asthma".
pH (2.3% honey ext.) = 4.30 ± 0.02
Total Ash = 9. 8 ± 0.7 % (w/w)
Total Water Extractive = 3.1 ± 0.1 % (w/w)
Net Weight = 14..93 ± 0.30 g
Species and straín
= Swiss albino rats
No. o animals Sex/group
= 30 male; 5 groups (N=6)
Route of admin.
Formulation and Dosage
= Herbaldecoction; 900, 1112, 1375, 1700, 2100 mg/k
Time of deaths and period of Observatíon
= Highest dose caused death at 8 houts after adnministration;
Approx. lethal dose and method of calculation
= 1533 mg/kg bodyweight; Probit analysis
= Crawling gait, twitching and tremor before death.
The LD50 in rats was estimated to be 1533mg/kg-body weight. No
death occurred at the lowest dose of 900 mg/kg-body weight. At
the highest dose of 2100 mg/kg-body weight symptoms of toxic
effects observed in rats were crawling gait, twítching
and tremor. In the acute toxícity studies, it was established
that the laboratory animals needed to consume almost 89 times
the normal adult dose (mix whole contents of sachet (15gm of
powder) in one beer bottle of honey (600 ml); take one tablespoonful
thrice daily) in order to produce acute toxic effect. No syniptoms
of toxic effects were- observed in rats at the dosage level iiidicated
by the manufacturer.
The LD50 of "Asthfin A1" is 89 times the dosage
indicated by the manufacturer. The recommended dose is thus within
an acceptable margin of safety.
S. Osafo - Mensah
DR. G. Duke - Eshun
Dr. A. A. Sittie
REPUBLIC OF GHANA
(MINISTRRY OF HEALTH)
CENTRE FOR SCIENTIFIC
RESEARCH INTO PLANT MEDICINE
W.H.O .COLLABORATING CENTRE FOR RESEARCH & DEVELOPMENT OF
Local Tel: 0872-22041 / 22103 Tel/Fax: 0872-22087
P.O. BOX 73
Mampong - Akuapem
Zastern Region, Ghana
TO COMPLETE A RESEARCH ON
ASTHFIN A1A MEDICINE FOR ASTHMA
This appeal goes to
Foundations for Medicaml Researches
I would be very grateful if you offer me financíal assistance
to enable me complete a research on a local medicine very potent
I began this rescarch a decade ago, and could confirm today that
1 have found an effectìve cure for asthma. I have already'
treated a few other patients and myself in my locality with it.
I now feel strongly that this medicine
should bo given a scientific touch and be developped into an
orthodox one to the bénefit of asthmatícs worldwide.
One positive indication about it is that its life, I believe,
could span well over five years.
Your assístance will go into the study of the adequate
dosage, the laboratory and clinical tests, and eventual submission
to the Food and Drugs Board for approval.
I have 'also registered with the Ghana Psychíc and Traditional
Healers Associafion under license No 337 dated 27th February
1997 to give legal backing to my findings
I have also received a letter of support for the project from
the Ketu Dístrict Assembly, P. .0. Box 88, Denu, V/R.
(Ghana) dated May 29th 2000, with reference No. KUDA / GEN. 24
/ VOL. 5/2 10.
Tlie World Health Organízatìon has already acknowledged
the project wíth referenee No. CRA dated 22nd February
2000, and sígned by Dr.N. Khaltaev, Responsible Officer
- Chronic Respiratory Diseases and Arthrítís, Non-commuunícable
Disease Management - World Health Organization - CH 1211 Geneva
27 - SWITZERLAND.
I have also submitted the medicine to the Centre for Scíentific
Rescarch ínto Plant Medicine, an affiliated body to the
World Health Organìzatíon (WHO) for Phytochemistry
and Pharmacology/toxicology tests under parcel No. 15011052 dated
October 1st 2002.
In another development I am working on Phycolin Syrup whích
when taken helps to stop cigarettes and marijuana smoking, since
smoking is one of the causes of asthma.
I will require ten thousand Pounds (£ 10,000) for the project..
I am eurrently the Ketu Distrìct
Secretary of Ghana Federation of Traditional and Alternative
Medicine Practitioners Associations (CHAFTRAM).
A publication on the religious magazine "Awake!", June
8 1999 issue, entitled "Asthma on the Rise"" has
sensitised me further to undertake the project more seriously,
and I quote: "Reports from the World Health Organisation
indicate that in the last decade, there has been a 40% (percent)
rise in both the prevalence of an hospitalisation rates for asthma
worldwide.... Presently there are about 1,5 million asthmatics
in Canada and 500 die every year from the disease."
I am full of convietion that dreadful nature of the disease and
plight of asthmatìcs coupled with your undersianding of
my determination to solve a human problem, and your sympathy
for asthmatics wìll prompt you give a due consíderatíon
to this passionate appeal.
and advice are most welcome.
I am also seekng grants to study vegetation in Japan, Malaysia,
Canada, United States, brazil, Australia etc